Composition
Actifast tablet: Each film coated tablet contains Ketorolac Tromethamine USP 10 mg.
Pharmacology
Ketorolac is a non-steroidal anti-inflammatory drug (NSAID). It inhibits synthesis of prostaglandins and may be considered as a peripherally acting analgesic. It is highly protein bound and is largely metabolized in liver. The products of metabolism and some unchanged drugs are excreted in the urine.
Indication
Ketorolac is very effective for the short-term management of moderate to severe pain.
Dosage & administration
Adults and Children (over 16 years): 10 mg every 4-6 hours as required.
Maximum daily dose is 40 mg, maximum duration of treatment is 7 days.
Contra-indication
Ketorolac is contraindicated in patients with known hypersensitivity to NSAIDs and any of the components of Ketorolac. Moreover, this drug is contraindicated in patients with history of asthma, nasal polyp, angioedema, peptic ulcer and bleeding disorders.
Warning & precaution
Precaution should be taken in elderly, allergic disorder, renal, cardiac and hepatic impaired patient with low body weight.
Side effects
Side effects of Ketorolac are anorexia, nausea, diarrhoea, abdominal pain, dyspepsia, headache, dizziness, restlessness, drowsiness, insomnia, dry mouth, acute renal failure, bradycardia, asthma etc.
Use in pregnancy & lactation
Pregnancy: Pregnancy category C.
Lactation: Contraindicated to nursing mother.
Use in children & adolescents
Not indicated for use in pediatric patients.
Drug interaction
Increased risk of haemorrhage when Ketorolac is given with anticoagulants and NSAIDs.
Overdose
Overdosage of Ketorolac Tromethamine may cause abdominal pain, peptic ulcers which healed after discontinuation of doses. Metabolic acidosis has been reported following intentional overdosage.
Storage
Keep out of the reach of children. Keep below 30°C, protect from light.
Packing
Actifast tablet: Each box contains 3x10's tablet in blister pack.
