Pantoprox

Presentation

Pantoprox tablet: Each enteric coated tablet contains Pantoprazole Sodium Sesquihydrate USP 22.56 mg equivalent to Pantoprazole 20 mg.

Description

It  is  a  proton  pump  inhibitor  that  suppresses  gastric  acid  secretion  by specific inhibition of the H+/K+ -ATPase in the gastric parietal cell. By acting specifically on the proton pump, Pantoprazole blocks the final step in acid production, thus reducing gastric acidity.

Indication

• Gastro-esophageal reflux disease (in the presence of erosive reflux esophagitis)

• Symptomatic treatment of Gastro-esophageal reflux disease(in the absence of esophagitis)

• NSAID associated gastric ulcer

• Duodenal ulcer associated with Helicobacter pylori

• Zollinger-Ellison Syndrome

Dosage and administration

Pantoprazole can be taken before or after meal.

Indication Dose & Frequency
Short term  treatment  of  Erosive Esophagitis associated With GERD Adult:Two  Pantoprox  tablets  once  daily for up to 8 weeks
Children (5 years and older):
≥ 15 kg to < 40 kg: One Pantoprox tablet once daily for up to 8 weeks
≥ 40 kg : Two Pantoprox tablets once daily for up to 8 weeks
Maintenance of Healing of Erosive Esophagitis Adults: Two Pantoprox tablets once dail
Pathological hypersecretory conditions including Zollinger-Ellison Syndrome Adults: Two Pantoprox tablets twice daily

Contraindication

Patients with known hypersensitivity to any component of the formulation.

Use in special group

Pregnancy:  This  drug  should  be  used  during  pregnancy  only  if  clearly needed.

Lactation:  The  excretion  of  Pantoprazole  in  breast  milk  has  not  been studied. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Precaution

Symptomatic response to therapy with Pantoprazole does not preclude the presence of gastric malignancy.

Drug interaction

Pantoprazole  inhibits  gastric  acid  secretion.  Therefore,  Pantoprazole  may interfere  with  the  absorption  of  drugs  where  gastric  pH  is  an  important determinant of bioavailability (e.g. Ketoconazole, Iron salts and Digoxin).

Storage

Keep out of the reach of children. Keep below 30°C, protect from light.

How supplied

Pantoprox Tablet: Each box contains 6x10’s tablet in blister pack.